If overgrowth of nonsusceptible bacteria, fungi, or yeasts occur, or if hypersensitivity develops, treatment should be discontinued and appropriate therapy instituted.ДЄdministration of recommended doses of OTOMAX ointment beyond 7 days may result in delayed wound healing. Antibiotic susceptibility of the pathogenic organism(s) should be determined prior to use of this preparation. PRECAUTIONS Identification of infecting organisms should be made either by microscopic roll smear evaluation or by culture as appropriate.

These events began rapidly and extensively after addition of the drug.Д¬lotrimazole is very poorly absorbed following dermal application. In studies of the mechanism of action, the minimum fungicidal concentration of clotrimazole caused leakage of intra-cellular phosphorus compounds into the ambient medium with concomitant breakdown of cellular nucleic acids and accelerated potassium efflux. In an induced otitis externa infected with Malassezia pachydermatis, 1% clotrimazole in the OTOMAX vehicle was effective both microbiologically and clinically in terms of reduction of exudate, odor, and swelling. Resistance to clotrimazole is very rare among the fungi that cause superficial mycoses.

In vitro, clotrimazole exhibits fungistatic and fungicidal activity against isolates of Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, Microsporum canis, Candida spp., and Malassezia pachydermatis ( Pityrosporum canis). The primary action of clotrimazole is against dividing and growing organisms. Clotrimazole: Clotrimazole is a broad-spectrum antifungal agent that is used for the treatment of dermal infections caused by various species of pathogenic dermatophytes and yeasts.

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